利用果蝇动物模型研究运动抗心脏衰老的分子机制     

吴越  郑澜 《科教文汇》2015,(11)

适宜规律的运动训练可以延缓心脏功能的生理性衰退,但其分子机制未知。目前采用哺乳动物模型研究这一机制存在诸多困境。果蝇的生命周期短、遗传背景简单、转基因技术成熟,一直是衰老基因筛选和功能研究的理想模式生物,得益于近年果蝇抗重力攀爬系统的开发,本文将依托前期实验成果阐述果蝇运动模型的建立方法与可行性,同时结合果蝇心脏功能检测技术说明果蝇运动模型研究抗心脏衰老分子机制的发展前景和局限性。  相似文献   

Cardiodynamicsgram: a novel tool for monitoring cardiac function in exercise training     

Xu Wen  Bokai Guo  Yinglan Gong  Ling Xia  Jie Yu 《Journal of sports sciences》2018,36(22):2583-2587

This study evaluated the feasibility of cardiodynamicsgram (CDG) for monitoring the cardiac functions of athletes and exercisers. CDG could provide an effective, simple, and economical tool for exercise training. Seventeen middle-distance race athletes aged 14–28 years old were recruited. CDG tests and blood test including creatine kinase (CK), CK-MB isoenzyme, and high-sensitivity troponin I (hsTnI) were performed before a high-intensity prolonged training, as well as 2 and 14 h after training, respectively. The CDG test result was unsatisfactory when the CK test result was used as standard. However, the accuracy of CDG test was about 80% when CK-MB and hsTnI were used as standards. Thus, CDG offers a noninvasive, simple, and economical approach for monitoring the cardiac function of athletes and exercisers during exercise training. Nonetheless, the applicability of CDG needs further investigation.  相似文献   

苦参碱对急性心衰猫心功能和血流动力学的影响   总被引：3，自引：0，他引：3  

罗学娅 刘倩黄彩云  黄胜英 《大连大学学报》1999,20(4):81-84

目的：研究苦参碱对急性心衰猫心功能和血流动力学的影响方法：以成巴比妥钠造成猫急性心衰模型,iv甘参碱20、40mg/kg,用多道生理记录仪和电磁流量计测定猫的心脏血流动力学参数．结果：苦参碱低、高剂量组均可使LVSP、±dp／dtmax、CO、CI、SI、LVWI显著增加,LVEDP、MAP、TPVR、HR显著下降;高剂量组作用强于低剂量组,给药后15min作用达峰值．结论：苦参碱对戊巴比妥钠诱发的心衰猫具有明显的正性肌力作用,负性频率作用,且能增强心脏舒缩功能,降低外周血管阻力,减轻心脏负荷．说明苦参碱有抗心衰作用．  相似文献   

Cadaveric Simulation Training in Cardiothoracic Surgery: A Systematic Review     

Davida A. Robinson  Diane T. Piekut  Linda Hasman  Peter A. Knight 《Anatomical sciences education》2020,13(3):413-425

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